Webb30 juni 2024 · Sub-thermoneutral housing temperatures confound preclinical metabolic research In response to a thermal challenge that threatens to lower core body … Webb13 jan. 2024 · Overall, these data suggest that thermoneutral housing may alter some aspects of cardiac remodeling in preclinical mouse models of heart failure. NEW & …
Warming the mouse to model human diseases - Nature
WebbThermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling Nonalcoholic fatty liver disease (NAFLD), a common prelude to cirrhosis and hepatocellular carcinoma, is the most common chronic liver … Webb11 nov. 2024 · Thermoneutral housing has been shown to promote more accurate and robust development of several pathologies in mice. Raising animal housing temperatures a few degrees may create a relatively straightforward opportunity to improve translatability of … jessi morse life below zero next generation
Manipulation of Ambient Housing Temperature To …
Webb23 juli 2024 · Modern humans are rarely, if ever, under such constant thermal stress. Thus, pre-clinical studies examining brown fat activation to treat obesity should incorporate … Webb25 nov. 2024 · Thermoneutral Housing Negates Brown Fat Defect and Restore Weight Gain upon High- fat Diet Condition in the DKO mice To confirm impaired brown adipose mitochondrial function, we housed both WT and DKO mice at thermoneutrality (TN, 30 °C), which excludes the BAT thermogenic effect (Boutant et al., 2024). Webb12 maj 2024 · The study found that compared with housing at 22 °C, thermoneutral housing accelerated the onset of metabolic inflammation in the white and brown … inspect pp 01 out 200082