WebP-selectin glycoprotein ligand-1 (PSGL-1) has long been studied as an adhesion molecule involved in immune cell trafficking and is recognized as a regulator of many facets of immune responses by myeloid cells. PSGL-1 also regulates T cell migration during homeostasis and inflammatory settings. However, recent findings indicate that PSGL-1 … WebFeb 2, 2014 · P-selectin glycoprotein ligand-1 (PSGL-1) was identified as the major ligand facilitating monocyte accumulation at metastatic sites. Reduced recruitment of …
Monocyte recruitment during infection and inflammation
WebAbout 30% of PSGL1 lo Ly6C lo T fh cells were Nur77 positive, with a slightly higher percentage in the CXCR5 hi PD1 hi T fh compartment . Whereas PD1 expression was … WebFeb 1, 2015 · Neutrophils lose their adhesiveness to blood vessels after infiltration, which includes an ectodomain shedding of P-Selectin Glycoprotein Ligand-1 (PSGL-1) on their surface. ... Ly6G (+) Ly6C (−) neutrophils and Ly6G (−) Ly6C (+) monocytes infiltrate into injured muscle similarly in wild type and Adam8 −/ ... csr vinyl based compounds sds
Signaling function of PSGL-1 in neutrophil: tyrosine ... - PubMed
WebDownload scientific diagram PSGL1 hi Ly6C lo compartment consists of fully differentiated Tfh and Th1 cells. (A–D) LCMV-specific Blimp1-YFP SM (CD45.1 + ) CD4 T cells were … WebOct 28, 2011 · Ly6C and p-selectin glycoprotein ligand 1 (PSGL1), and in some cases folate receptor 4 (FR4), have also been used to study the heterogeneity of CD4 + effector T-cell populations induced by... WebThere were no significant differences in percentages and numbers of splenic CD4 + CD44 hi Ly6c lo PSGL-1 lo Tfh cells in differently aged MRL lupus-prone mice (Supplemental Figure 1A) (25, 28). Open in a separate window. Figure 1. Temporal formation of Tfh and Th1 cells during different stages of disease. Spleens were harvested from either B6. ear anatomy for piercing