WebApr 21, 2024 · Formally, we consider the optimal sequence-to-graph alignment problem, the task of finding an optimal base-to-base correspondence between a query sequence … WebAug 1, 2024 · A graph-based genome indexing scheme enables variant-aware alignment of sequences with very low memory requirements. This work presents a method …
Haplotyping interspecific hybrids by dual alignment to both …
WebApr 9, 2014 · Genome alignment with graph data structures: a comparison Abstract. Recent advances in rapid, low-cost sequencing have opened up the opportunity to … WebSep 14, 2024 · Graph genomes. The first reference genome sequences were entirely linear from a single or few individuals, but such a representation is not sufficient for encompassing all of the genomic variation present in a population. The human reference GRCh37 adopted a graph-based representation, by introducing the concept of … phonky town by playaphonk
Fast and accurate genomic analyses using genome graphs
WebOct 4, 2024 · Genotyping is a core application of high-throughput sequencing. We present KAGE, a genotyper for SNPs and short indels that is inspired by recent developments within graph-based genome representations and alignment-free methods. KAGE uses a pan-genome representation of the population to efficiently and accurately predict genotypes. … WebMar 16, 2024 · HISAT2 is a fast and sensitive alignment program for mapping next-generation sequencing reads (whole-genome, transcriptome, and exome sequencing … WebThe human reference genome represents only a small number of individuals, which limits its usefulness for genotyping. We present a method named HISAT2 (hierarchical indexing for spliced alignment of transcripts 2) that can align both DNA and RNA sequences using a graph Ferragina Manzini index. how does a 35mm film camera work