Chalcoplatin
WebMay 15, 2024 · 3. Drug targeting and delivery systems. Selective drug delivery is an important approach with great potential for overcoming problems associated with the systemic toxicity of chemotherapy, in particular, platinum-based chemotherapy [23, 24].Targeted drug therapy has two advantages over conventional chemotherapy: … WebChalcoplatin significantly induced p53 activation as well as the subsequent apoptosis pathways. This unique mode of action renders chalcoplatin remarkably cytotoxic and …
Chalcoplatin
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WebDec 30, 2024 · Probably, the most prominent example of this perception is so far represented by monochalcoplatin (Figure 1) that was extremely more active than its symmetric homologue chalcoplatin, despite its higher lipophilicity and the ability to deliver two active chalcone molecules from the latter (chalcone is an inhibitor of the p53 mouse … WebJan 27, 2015 · Chalcoplatin significantly induced p53 activation as well as the subsequent apoptosis pathways. This unique mode of action renders chalcoplatin remarkably …
WebJan 27, 2015 · Chalcoplatin significantly induced p53 activation as well as the subsequent apoptosis pathways. This unique mode of action renders chalcoplatin remarkable … WebChalcoplatin, a dual-targeting and p53 activator-containing anticancer platinum (iv) prodrug with unique mode of action L Ma, R Ma, Y Wang, X Zhu, J Zhang, HC Chan, X Chen, W Zhang, ... Chemical Communications 51 (29), 6301-6304 , 2015
WebChalcoplatin significantly induced p53 activation as well as the subsequent apoptosis pathways. This unique mode of action renders chalcoplatin remarkably cytotoxic and makes this compound among the first examples of a Pt(iv) prodrug that directly interacts with the downstream pathway after the formation of Pt-DNA lesions. This journal is WebOct 1, 2024 · Europe PMC is an archive of life sciences journal literature.
WebHere we report the discovery and evaluation of monochalcoplatin, a monocarboxylated PtIV prodrug that is among the most cytotoxic PtIV prodrugs to date. Compared with its …
WebMay 28, 2024 · Recently, Pt IV prodrugs have attracted much attention as the next generation of platinum-based antineoplastic drug candidates. Here we report the discovery and evaluation of monochalcoplatin, a … final countdown f 14 vs zero youtubefinal countdown drWebJun 14, 2024 · Compared with its dicarboxylated counterpart chalcoplatin, monochalcoplatin accumulates astonishingly effectively and rapidly in cancer cells, which is not ascribed to its lipophilicity. The prodrug is quickly reduced, causes DNA damage, and induces apoptosis, resulting in superior cytotoxicity with IC50 values in the nanomolar … grunkies bayfield wisconsinWebJul 19, 2024 · 1. Introduction. The discovery of anticancer properties of platinum based complexes became a significant breakthrough in cancer treatment [].Currently cisplatin, carboplatin, and oxaliplatin remain major drugs for the first line treatment (alone and in combination) for a variety of malignancies including head and neck, testicular, breast, … final countdown dogfight with zerosWebSep 8, 2024 · Notably, cisplatin (CDDP) has become one of the most efficient platinum (II) complexes used in cancer chemotherapy, and the mechanism is binding to nuclear DNA … final countdown europe tabWebChalcoplatin, a dual-targeting and p53 activator-containing anticancer platinum(IV) prodrug with unique mode of action final countdown europe testoWebMay 1, 2015 · Abstract. A nanoplatform targeting DNA and p53 simultaneously is assembled. Layered double hydroxide nanoparticles are co-loaded with a Pt (IV) prodrug and a p53 activator. Once inside cells, cisplatin is released to attack genomic DNA and kill cancer cells; simultaneously, the p53 activator results in active p53, a key protein … final countdown europe text