Breast cancer klf5

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August undefined, 2024

WebExpression of KLF5 (BTEB2, CKLF, IKLF) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. WebThe National Library of Medicine (NLM), on the NIH campus in Bethesda, Maryland, is the world's largest biomedical library and the developer of electronic information services that delivers data to millions of scientists, health professionals and members of the public around the globe, every day.

USP3 promotes breast cancer cell proliferation by deubiquitinating KLF5 …

WebMay 16, 2009 · KLF5 has potential as a biomarker for diagnosis and prognosis in cancers and cardiovascular diseases. The expression of KLF5 mRNA associates with reduced survival in patients with breast cancer . … WebAug 30, 2024 · In addition to KLF5, AXL is an EMT-induced regulator of cancer metastasis, controlled by Slug and Vimentin in breast cancer [17, 39–41]. Thus, the total AXL protein levels might also be lowered by EMT transcription factors, such as Slug or other transcription factors that have been changed by DCC-2036, which should be further … meatloaf recipe with rice as a filler

Role of KLF5 in Hormonal Signaling and Breast Cancer …

WebApr 21, 2016 · The Kruppel-like factor 5 (KLF5) transcription factor is highly expressed in high-grade and basal-like breast cancers. However, the mechanism by which KLF5 … WebFigure 8.1. Relationships between steroid hormones and KLF5 in breast cells. ① Estrogen and ERα induce the expression of the EFP E3 ubiquitin ligase, which targets KLF5 for degradation in ERα-positive breast cancer cells. ② KLF5 interacts with ERα to suppress ERα-mediated transcription of c-Myc and CSTD in ERα-positive breast cancer cells. ③ … WebMar 19, 2024 · Breast cancer, cervical cancer, hepatocellular carcinoma, and bladder cancer are all aided by KLF5 [29–31]. Furthermore, KLF5 expression has been linked to a poor prognosis in lung cancer, and in vitro tests have shown that a decrease of KLF5 may overcome cisplatin resistance in lung cancer [ 32 ]. peggy shomo joyner

YB-1 is a positive regulator of KLF5 transcription factor in …

Progesterone Receptor Positive Breast Cancer - an overview ...

WebJul 12, 2024 · Breast cancer is the most common disease and the leading cause of cancer-associated mortality in women worldwide . At present, several strategies are employed for the treatment of early breast cancer, ... KLF5, a downstream protein of YAP, had the lowest expression in the UM+SIM group (Fig. 4A). According to our previous study, the expression of TNFAIP2 mRNA is induced by KLF5 in TSU-Pr1 cells.20 To further test whether TNFAIP2 is a KLF5 target gene, we first examined KLF5 and TNFAIP2 protein levels in three immortalized breast epithelial cell lines (MCF10A, 184A1 and 184B5), six TNBC cell lines … See more To test whether KLF5 positively regulates TNFAIP2 mRNA expression in breast epithelial cell lines, we first knocked down KLF5 in MCF10A (Figure 2a) and BT20 (Supplementary … See more It has been well established that KLF5 promotes cell proliferation in part through FGF-BP and mPGES1.17, 18, 29 Because the function of TNFAIP2 has never been studied in breast … See more Filopodia and lamellipodia regulate cell morphology, adhesion, migration and invasion.30 It has been reported that TNFAIP2 is associated with actin cytoskeleton and the … See more KLF5 has been shown to promote keratinocyte cell migration.19 To determine whether KLF5 promotes TNBC cell adhesion, … See more peggy shirleyWebJul 11, 2007 · In a recent study, patients with breast cancer having higher KLF5 expression had both shorter disease-free survival and overall survival and the result of the study showed that KLF5 expression is a prognostic factor for breast cancer (Tong et al. 2006). However, it plays an inhibitory role in cell growth in cancer cells as well. ... peggy shorey

"WebDec 10, 2013 · KLF5 function is aberrantly affected at the protein level in breast cancer, through excessive protein degradation or enhanced cytoplasmic localization 58, 63. Loss of the 13q21-q22 genomic region, … " - Breast cancer klf5

Breast cancer klf5

BAP1 promotes breast cancer cell proliferation and …

WebJan 24, 2024 · Background Metastasis causes the majority of cancer-related deaths worldwide. Increasing studies have revealed that circRNAs are associated with the carcinogenesis and metastasis of many cancers. Nevertheless, the biological mechanisms of circRNAs in breast cancer (BC) liver metastasis remain extremely ambiguous. … WebMay 9, 2024 · Introduction. Breast cancer is still the most malignant female tumor in the world. It has been estimated that about 249,260 new cases and 40,890 deaths from …

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WebMar 1, 2024 · KLF5 is a transcription factor up-regulated in basal-like breast cancers. 29 Overwhelming evidence has shown that KLF5 induces cell proliferation, cell survival, and tumor growth. 30, 31, 32 Furthermore, lower KLF5 expression in breast cancer patients has been correlated with a better survival prognosis. 15, 16 More importantly, KLF5 is ... WebSep 30, 2015 · The transcription factor KLF5 is highly expressed in basal-like breast cancer and promotes breast cancer cell proliferation, survival, migration and tumour growth. …

WebJan 13, 2024 · A Western blotting showed the expression of KLF5, YB-1 and DACH1 in immortalized mammary epithelial and breast cancer cell lines.B The analysis of … WebNov 11, 2024 · We conclude that USP3 confers drug resistance in breast cancer cells independently of KLF5. Discussion. KLF5 has been implicated as an oncogene and therapeutic target in a number of cancers including breast, colon, bladder, lung, stomach, and ovarian cancer . Therefore, it is important to thoroughly understand the upstream …

WebHere, based on clinical database, we demonstrate a positive correlation between Kruppel-like factor 5 (KLF5) and YB-1 expression in breast cancer patients, but a negative correlation with that of Dachshund homolog 1 (DACH1). Mechanistically, YB-1 enhances KLF5 expression not only through transcriptional activation that can be inhibited by … WebMay 1, 2007 · Breast cancer is described as heterogeneous because it is a different disease in different women, a different disease in different age groups and has different cell populations within the tumor itself. ... Downregulation and growth inhibitory effect of epithelial-type Krüppel-like transcription factor KLF4, but not KLF5, in bladder cancer ...

WebOct 17, 2024 · The Krüppel-like factor 5 (KLF5) transcription factor is highly expressed in basal type breast cancer and promotes breast cancer cell proliferation, survival, migration, and tumorigenesis.

WebSep 24, 2013 · In breast cancer cells, KLF5 promotes proliferation by upregulating the cell cycle genes cyclin A2 (CCNA2), chromatin licensing and DNA replication factor 1 (CDT1), which is a member of the pre ... meatloaf recipe with panko crumbsWebJun 19, 2009 · Krüpple-like transcription factor 5 (KLF5) is a zinc-finger transcription factor promoting cell survival and tumorigenesis in multiple cancers. A high expression level of … meatloaf recipe with onions and green peppersWebIn breast cancer, KLF5 promotes cancer cell proliferation and the cell cycle by inducing transcription of FGF-BP1, 25 mPGES1, 26 TNFAIP2, 27 and Cyclin D1 4 and inhibiting transcription of p27 5 and p21. 26 KLF5 maintains cell stemness by inducing the transcription of Slug 7 and Nanog. 6 KLF5 is essential for progesterone to induce cell ... peggy shirley obituaryWebJan 12, 2024 · SRC is the first identified oncogene, and its aberrant activation has been implicated as a driving event in tumor initiation and progression. However, its role in cancer stemness regulation and the underlying regulatory mechanism are still elusive. Here, we identified a YAP1 tyrosine phosphorylation-dependent YAP1-KLF5 oncogenic module, … meatloaf recipe with red wine vinegar glazeWebJan 1, 2024 · These findings collectively suggest that TNFAIP2 is a direct KLF5 target gene, and both KLF5 and TNFAIP2 promote breast cancer cell proliferation, migration and invasion through Rac1 and Cdc42 ... meatloaf recipe with peppersWebThe long noncoding RNA (lncRNA) LINC00152, also known as CYTOR, displays aberrant expression in various cancers. However, its clinical value and functional mechanisms in breast cancer remain insufficiently understood. Our study found that LINC00152 is significantly upregulated in breast cancer, and that it acts as an indicator of poor … peggy shoots filmWebMay 28, 2024 · In breast cancer, KLF5 plays oncogenic roles by regulating a wide range of downstream genes. For example, KLF5 induces the transcription of Cyclin D1, FGF-BP1, mPGES1, TNFAIP2 and Slug, while it suppresses the transcription of p27 and p21 to promote cell proliferation [20, 21]. However, previous studies on KLF5 have mainly … meatloaf recipe with pepperidge farm stuffing